EM - Esclerose Múltipla
Saiba mais sobre MS
A abordagem BodyScience
Como funciona o nosso tratamento ?
É especialmente importante entender que este programa foi desenvolvido para melhorar sua mobilidade, força, respiração, atividades da vida diária e aumentar sua amplitude de movimento e liberdade. uma cura, mas sim uma maneira eficaz de melhorar substancialmente sua vida.
Para pessoas com cuidadores, este programa é ótimo, muitas vezes permite levantar, alimentar e ir ao banheiro com mais facilidade.
Nosso programa é individualizado para suas necessidades específicas, se a respiração é a área de maior desconforto, é a área em que começamos.
As condições neuromusculares requerem três áreas de foco de tratamento:
(1) nutrição para os músculos;
(2) energia para as células, neurônios, e suas mitocôndrias
(3) signalers to melhora a capacidade de sobrevivência dos neurônios e reduz a morte dos neurônios.
Os tratamentos começam na segunda-feira e vão até sexta-feira. Muitos de nossos pacientes permanecem por duas a três semanas.
Types of MS
There are three main types of multiple sclerosis:
1. Relapsing-remitting MS (RRMS): The most common form, characterized by periods of symptom flare-ups followed by remissions[3].
2. Secondary progressive MS: Symptoms gradually worsen over time, often following an initial relapsing-remitting course[2].
3. Primary progressive MS: Symptoms slowly worsen from the onset without distinct relapses or remissions[2].
Early diagnosis and treatment can help manage symptoms and potentially slow the progression of the disease. While there is no cure for MS, various treatments and lifestyle modifications can help improve quality of life for those affected by the condition[1][5].
Citations:
[1] https://www.mayoclinic.org/diseases-conditions/multiple-sclerosis/symptoms-causes/syc-20350269
[2] https://www.nhs.uk/conditions/multiple-sclerosis/
[3] https://www.webmd.com/multiple-sclerosis/what-is-multiple-sclerosis
[4] https://www.ninds.nih.gov/health-information/disorders/multiple-sclerosis
[5] https://my.clevelandclinic.org/health/diseases/17248-multiple-sclerosis?ftag=YHF4eb9d17
[6] https://www.pennmedicine.org/for-patients-and-visitors/patient-information/conditions-treated-a-to-z/multiple-sclerosis-ms
[7] https://www.mssociety.org.uk/about-ms/signs-and-symptoms/early-signs-of-ms
[8] https://www.nationalmssociety.org/understanding-ms/what-is-ms/ms-symptoms
What are the potential reasons for Multiple Sclerosis
Multiple sclerosis (MS) is a complex autoimmune disease with no single definitive cause. However, research has identified several potential factors that may contribute to its development:
Genetic Factors
Genetics play a role in MS susceptibility, though no single gene has been identified as the cause:
Having a parent or sibling with MS increases your risk, though it remains relatively low overall[2][4].
Over 150 genetic variants have been associated with increased MS risk[2].
Environmental Factors
Several environmental factors have been linked to MS development:
Geographic Location
MS is more common in temperate climates, including Canada, northern US, New Zealand, southeastern Australia, and Europe[4].
Living farther from the equator is associated with higher MS rates[1].
Vitamin D and Sunlight Exposure
Low vitamin D levels and reduced sunlight exposure are linked to increased MS risk[2][4].
A person's birth month may affect MS risk, possibly due to maternal sunlight exposure during pregnancy[4].
Infections
Certain viruses have been associated with MS, particularly the Epstein-Barr virus (which causes mononucleosis)[2][4].
Smoking
Cigarette smoking significantly increases the risk of developing MS and can worsen disease progression[1][2][4].
Diet and Obesity
High-fat diets and obesity, especially in females during childhood and adolescence, are associated with increased MS risk[2][4].
Other Risk Factors
Additional factors that may influence MS development include:
Age: MS typically first appears between ages 20 and 40[4].
Sex: Women are 2-3 times more likely to develop relapsing-remitting MS than men[4].
Race: White people of Northern European descent have the highest risk, while those of Asian, African, and Native American ancestry have lower risk[4].
Other autoimmune conditions: Having certain autoimmune diseases slightly increases MS risk[4].
Immune System Dysfunction
The underlying mechanism of MS involves the immune system mistakenly attacking the myelin sheath that protects nerve fibers in the brain and spinal cord[5]. However, the exact trigger for this autoimmune response remains unknown.
It's important to note that while these factors may increase the risk of developing MS, the precise cause is likely a complex interaction between genetic predisposition and environmental triggers[2][4].
Citations:
[1] https://mymsaa.org/ms-information/overview/possible-causes/
[2] https://www.yalemedicine.org/conditions/multiple-sclerosis-ms
[3] https://www.nhs.uk/conditions/multiple-sclerosis/
[4] https://www.mayoclinic.org/diseases-conditions/multiple-sclerosis/symptoms-causes/syc-20350269
[5] https://www.webmd.com/multiple-sclerosis/multiple-sclerosis-causes
[6] https://www.ninds.nih.gov/health-information/disorders/multiple-sclerosis
[7] https://my.clevelandclinic.org/health/diseases/17248-multiple-sclerosis?ftag=YHF4eb9d17
[8] https://www.nationalmssociety.org/understanding-ms/what-is-ms/what-causes-ms
What are the different types of multiple sclerosis
There are three main types of multiple sclerosis (MS):
Relapsing-Remitting MS (RRMS)
The most common form, affecting about 85% of people with MS at diagnosis[1][2]
Characterized by temporary flare-ups (relapses) followed by periods of remission[1]
Symptoms worsen during relapses and may improve partially or completely during remissions[1]
Secondary-Progressive MS (SPMS)
Often develops following initial RRMS[1][2]
Symptoms steadily worsen over time, with or without relapses[1]
Can be further classified as "active" (with relapses) or "non-active" SPMS[2]
Primary-Progressive MS (PPMS)
Affects about 10-15% of people with MS[1][2]
Symptoms gradually worsen from the onset without distinct relapses or remissions[1][3]
Typically involves more spinal cord lesions and less brain inflammation compared to RRMS[4]
Some sources also mention a fourth, less common type:
Progressive-Relapsing MS (PRMS)
Characterized by steady worsening from onset with occasional relapses[2]
This classification is becoming less frequently used as MS types are further studied and redefined[2]
It's important to note that MS affects each person differently, and the course of the disease can vary. Additionally, without treatment, many people with RRMS may eventually transition to SPMS, though modern disease-modifying therapies have reduced this progression[2].
Citations:
[1] https://www.webmd.com/multiple-sclerosis/what-is-multiple-sclerosis
[2] https://mymsaa.org/ms-information/overview/types/
[3] https://www.nhs.uk/conditions/multiple-sclerosis/
[4] https://www.healthline.com/health/multiple-sclerosis/types-of-ms
[5] https://www.msaustralia.org.au/types-of-ms/
[6] https://www.ninds.nih.gov/health-information/disorders/multiple-sclerosis
[7] https://www.mssociety.org.uk/about-ms/types-of-ms
[8] https://www.webmd.com/multiple-sclerosis/multiple-sclerosis-understanding-the-differences-in-ms
What are the early signs of relapsing-remitting MS
The early signs of relapsing-remitting multiple sclerosis (RRMS) can vary from person to person, but typically include:
Vision Problems
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Blurred vision
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Double vision
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Eye pain
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Partial or complete vision loss[1]
Sensory Disturbances
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Numbness, especially in the feet[1]
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Tingling sensations[3]
Motor Symptoms
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Muscle weakness[1][3]
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Difficulty walking or balance issues[3]
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Stiffness or muscle spasms[3]
Fatigue
Severe tiredness[1][3]
Other Common Early Signs
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Sensitivity to heat[1]
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Dizziness[3]
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Pain that runs down the spine when bending the neck[3]
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Bladder or bowel problems[3]
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Sexual dysfunction[3]
Cognitive and Emotional Changes
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Trouble thinking clearly[1][3]
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Depression[1]
It's important to note that RRMS symptoms typically:
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Develop over 2-3 days
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Last for 2-3 weeks
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Gradually improve, often completely, especially in early stages of the disease[2]
RRMS relapses are characterized by the sudden onset of symptoms that are obviously wrong and persist for more than a couple of days[2]. If you experience any of these symptoms, especially if they last more than 24 hours, it's crucial to consult a healthcare provider for proper evaluation and diagnosis.
Citations:
[2] https://www.webmd.com/multiple-sclerosis/video/video-rrms-relapse-signs
[3] https://www.webmd.com/multiple-sclerosis/relapsing-remitting-multiple-sclerosis
[4] https://www.yalemedicine.org/news/how-to-manage-multiple-sclerosis-ms-relapses
[5] https://www.healthline.com/health/multiple-sclerosis/types-of-ms
[6] https://www.webmd.com/multiple-sclerosis/multiple-sclerosis-understanding-the-differences-in-ms
[7] https://www.ninds.nih.gov/health-information/disorders/multiple-sclerosis
[8] https://www.webmd.com/multiple-sclerosis/what-is-multiple-sclerosis
What role does genetics play in the development of RRMS
Genetics plays a significant role in the development of relapsing-remitting multiple sclerosis (RRMS), though it is not the sole determining factor. Here are the key points about the genetic aspects of RRMS:
Genetic Risk Factors
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Multiple genes are involved in RRMS susceptibility, with over 200 genetic variants identified as potential risk factors[3].
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The strongest genetic risk factor is associated with variations in the HLA-DRB1 gene, particularly the HLA-DRB115:01 variant[3].
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Other genes like IL7R have also been linked to increased RRMS risk[3].
Inheritance Pattern
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RRMS is not inherited in a simple Mendelian pattern, but rather has a complex polygenic inheritance[3][4].
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Having a close relative (parent or sibling) with MS increases an individual's lifetime risk to about 3%, compared to 0.1-0.3% in the general population[4].
Genetic-Environmental Interaction
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Genetics alone does not determine if someone will develop RRMS. Environmental factors also play a crucial role[5].
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The interplay between genetic predisposition and environmental triggers (like vitamin D deficiency, Epstein-Barr virus exposure, or smoking) likely contributes to disease development[3][4].
Ongoing Research
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Genome-wide association studies (GWAS) have revolutionized MS genetics research, uncovering numerous genetic loci implicated in the disease[2].
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Many of the identified genetic variants are involved in immune system regulation, supporting the autoimmune nature of RRMS[4].
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While genetics significantly influence RRMS risk, it's important to note that having genetic risk factors does not guarantee disease development. The complex interplay between multiple genes and environmental factors ultimately determines an individual's susceptibility to RRMS.
Citations:
[1] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10337274/
[2] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6027932/
[3] https://medlineplus.gov/genetics/condition/multiple-sclerosis/
[4] https://www.healthline.com/health/multiple-sclerosis/possible-causes
[5] https://www.medicalnewstoday.com/articles/is-multiple-sclerosis-genetic
[6] https://www.ninds.nih.gov/health-information/disorders/multiple-sclerosis
[7] https://www.sciencedirect.com/science/article/abs/pii/S2211034819300318
[8] https://www.webmd.com/multiple-sclerosis/multiple-sclerosis-understanding-the-differences-in-ms